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This perception changed with the discovery of the Switch-II Pocket (S-IIP) in KRAS G12C

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Mice treated with low dose (10 mg/kg) or high dose (30 mg/kg) of luteolin before sensitization to HDM resulted in the decrease of sneezing, nose scratching, and HDM-specific IgE, without affecting total IgE, IgG1, or IgG2a levels (Figure 7B, C)

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