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Lipopolysaccharides (LPS) produced by harmful bacteria may infiltrate into the bloodstream through the portal vein, resulting in endotoxemia and inflammatory reactions, leading to inflammation of important organs related to metabolism, such as the liver and pancreas, as well as changes in the composition and number of intestinal flora

TMEM16K has been associated with several cellular phenomena, including spindle formation 20 , Ca 2+ signalling 21 , volume regulation 10 and apoptosis 20,21