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In relation to the IGF-1 LR3 pathway, this suggests that enhanced IGF-1 signaling can effectively promote muscle repair, regeneration, and growth, while myostatin continues to provide a level of regulation to maintain controlled tissue development

In the SELECT trial, patients did not enroll for the specific purpose of weight loss and received standard of care covering management of CV risk factors, including medical treatment and healthy lifestyle counseling, but without a specific focus on weight loss

doi: 10.3390/ijms19092523 74 AndersonEDurstineJL

Symptoms can also vary depending on the severity of the deficiency