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In order to maximize the clinical utility, various biomimetic approaches have been adopted to enhance or optimize the integrin-mediated cellular interactions and adhesion, including incorporation or surface modification with bioactive molecules or bioadhesive ECM motifs, and macro- or nano-scale patterning of the biomaterials [181]

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The secretory activity of microglia plays an essential role in the maintenance of synaptic function, the proliferation and maturation of oligodendrocytes and the recruitment of other immune cells