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Whether administration of leptin could overcome leptin resistance and exert an anti-obesity effect was tested in a placebo-controlled study with 47 obese men and women given varying doses of recombinant human leptin (0.03 mg/kg and 0.30 mg/kg, respectively) for 24 weeks and advised to eat 500 kcal less than body requirements each day

But those trials were small (approximately 300 subjects total across phases), short (up to 24 weeks), and used a route of administration that likely delivered minimal systemic exposure

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They appear together on clinic menus, in wellness stacks, on podcasts