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(131) demonstrated that supplementing with Lachnospiraceae bacterium strains significantly alleviated neutrophil infiltration and oxidative stress in ethanol-exposed mouse livers, exhibiting remarkable hepatoprotective effects

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Zhang et al., 2018b)

However, their contribution is context-dependent, as genetic ablation of ABCC1 does not fully prevent apoptosis-associated GSH loss in certain models 43 , indicating the existence of compensatory or alternative efflux mechanisms