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Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

Bearing in mind an estimated 8-10% prevalence of vitamin B12 deficiency among the population of this age group, an initial sample of 3556 patients will need to be recruited

Additionally, SIRT1 controls the activity of GCs to regulate the release of ovarian steroid hormones 95

EGT is sequestered within mitochondria through organic cation transporters, thereby preserving redox equilibrium and enhancing respiratory efficiency (24)