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Loading a pill with the enzyme was a consideration, but the need for oxygen and riboflavin in a form that may not be possible for us to supply made this a nonideal concept

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Randomized controlled clinical trials (RCTs) are regarded as the preferred evidence base, while other sources of real-world evidence (observational studies, registries, etc.) may be considered when RCT data are insufficient

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Lancet Rheumatol 5:e508e522 Wu Y, Hanson SW, Culbreth G et al (2024) Assessing the impact of health-care access on the severity of low back pain by country: a case study within the GBD framework