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Recommendations for selenium intake Although we lack evidence that selenium supplementation results in clinical improvement in autoimmune thyroiditis (other than in mild Graves orbitopathy), it still makes sense to ensure that selenium intake is adequate, given the roles played by selenoproteins in human health ( Reference Rayman 100 ) and particularly in the thyroid ( Reference Schomburg 70 , Reference Schomburg and Kohrle 71 )

Nonetheless, the target PK and PD levels determined from the translational work presented here were pivotal for the definition of the RP2D [27]

In contrast, in diabetic patients, the decrease in glucose uptake due to systemic and cardiac IR promotes a shift of substrates toward increased oxidation of free FA (FFA), resulting in reduced efficiency of cardiac metabolism

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