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This safety profile makes supplementation low-risk even when not strictly necessary

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Folate and B12 are metabolic partners: they work together to convert homocysteine to methionine, and both are essential for DNA synthesis and red blood cell formation

5.4 Circadian regulation of autonomic nervous system (ANS) activity to attenuating BBB dysfunction of IS Sympathetic and parasympathetic activities exhibit circadian rhythmicity and modulate cerebrovascular function through neurovascular coupling mechanisms (152, 153).Sympathetic activity predominates during the daytime, whereas parasympathetic activity is enhanced at night (154)