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JAK/STAT signaling via IL-6/IFN- upregulates hepcidin, blocking iron export, while IRF1 inhibits SLC7A11, reducing glutathione and GPX4 activity (Kowdley et al., 2021

4.4 Intrathecal administration Intrathecal (IT) delivery involves administering the chelator directly into the CSF (often via lumbar puncture or an implanted reservoir), thereby bypassing the BBB (Fowler et al., 2020)

In the context of airway epithelial injury, 13-HODE was shown to induce hyperresponsiveness, cell damage, and neutrophilia 59,79