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doi: 10.3389/fphar.2021.629379 217 WilesMD

The urinary antiproliferative factor (APF), which has been recently identified in the context of IC, acts to hinder cell growth and disrupts the repair of the damaged or worn-away urothelium, leading to alterations in the barrier function of the bladder lining (Sant, 2002)

The activation phase The second exposure is when symptoms explode

However, it is not clear whether this is strictly a ligandin function as Zea mays GSTU1 is able to catalyze the conjugation of GSH on protoporphyrinogen IX and harderoporphyrinogen (Dixon et al., 2008)