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One way in which Htt aggregates could cause toxicity is through depleting ubiquitin, a protein that binds to misfolded proteins to promote their clearance through the ubiquitin-proteasome system ( Notably, the N-terminal 17-residue domain stretch of huntingtin folds into an amphipathic -helix in the presence of membranes (Pandey et al., 2018)

Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

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The idea behind it is genuinely elegant: rather than tweaking brain chemicals the way caffeine or a stimulant does, dihexa was supposed to help neurons physically grow new synapses the connection points where brain cells talk to each other