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Conversely, Habif et al

Compared with traditional therapy modalities, nanoparticles improve the targeting efficiency of mitochondria, enhance the stability and bioavailability of therapeutics, and reduce the side effects on other non-target sites

Regarding the modulation of the expression of MMPs, proteins that promote the remodeling of the extracellular matrix (ECM) [59] , melatonin achieves this repressive effect by inhibiting the p38 MAPK signaling pathway through PKA, exerting a negative effect on transcription by NF-kB, and even by docking directly at the MMP-9 activation site [28,62]

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