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We found that serum levels of the lipid peroxidation marker 4hydroxynonenal (4HNE) were significantly increased in aged (11monthold) VEGFA hyper mice, but not in young (6weekold) VEGFA hyper mice, when compared with age and gendermatched control littermate mice, suggesting an agedependent increase in oxidative stress in these mice as a consequence of increased VEGFA levels (Fig 2C)

Functional studies have identified many key genes that mediate breast cancer organ-specific metastasis, and the expression of these genes in the primary tumor is likely to forecast the patients organ-specific metastasis (100, 101)

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