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At the anterior pole, BMAL1 labelling was mainly detected in the epithelium, with less labelling evident in the fiber cells for each time point ( Figures 5AD )

This leads to disruptions in the transcription of proteins vital to the mitochondrial ETC, thus inducing malfunction and hindering ATP synthesis, which in turn might escalate ROS generation [113]

Nanoemulsions also often show improved bioavailability of actives because the small droplets have a huge surface area for digestion, and the encapsulated nutraceuticals can be more readily absorbed

Recent studies have revealed that MERCs play a role in the regulation of cell division, and HMOX2 has been identified as an iron source for cell proliferation 22,46