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Finally, a recent 2021 study performed in a paediatric population (03 years) in Turkey found that a sublingual methyl-Cbl treatment regimen, comprising 1 mg daily replacement for a week followed by every other day for 2 weeks, 2 days/week for 2 weeks and once a week for 3 months was as effective as similar dose schedules of IM and oral CN-Cbl at normalising B12 levels (Orhan Kili et al., 2021)

inserted a TH -P2A-TdTomato cassette into the endogenous TH locus and generated isogenic hPS cell lines harboring PD-associated gene mutations, including PARKIN ( PRKN ), DJ-1 ( PARK7 ) and ATP13A2 ( PARK9 )

Supporting this, we have consistently replicated our findings in both B and T-ALL cells across diverse genetic subtypes