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Nonetheless, it is important to highlight that the presence of AMPA and GLY in environmental matrices (e.g., groundwater, wastewater treatment plant effluents, or sewage sludge) may not arise solely from the agricultural use of GBHs and GLY metabolism: the notion has been raised that they may also originate from phosphonate-based detergents and chelating agents used in various cleaning products, household or industrial applications, and during wastewater treatment (Grandcoin et al

This subsequently contributes to the pathophysiological progression of type 2 diabetes, obesity-related metabolic syndrome, and microvascular complications (diabetic nephropathy, retinopathy)