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CREB signaling induces Bcl-2 (B- cell lymphoma) and BIRC3 (Baculoviral IAP repeat containing 3), a caspase protein, and exerts anti-apoptotic effects that in turn signal insulin receptors to release insulin [8]

Taken together, serotonin can also decrease the necrosis region of the liver and improve the 5-day's survival

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Meanwhile, novel payloads, including IDO inhibitors, PARP inhibitors, and epigenetic modulators, are expanding ADC functions beyond cytotoxicity toward immune activation and tumor reprogramming [41, 42]