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In the PRECISE-IVUS (Plaque Regression With Cholesterol Absorption Inhibitor or Synthesis Inhibitor Evaluated by Intravascular Ultrasound) trial, patients randomized to receive combination therapy of atorvastatin plus ezetimibe experienced a greater reduction in percent plaque volume at 9-12 month follow-up (-5.2%, n=100) than those who received monotherapy (atorvastatin alone

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Proteasome inhibition induces DNA damage and reorganizes nuclear architecture and protein synthesis machinery in sensory ganglion neurons

S1), which may explain the very low response reported in an earlier study [14]