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Histone modification, a multifaceted process, involves diverse mechanisms such as lactylation, methylation, ubiquitination, acetylation, phosphorylation, and adenosine diphosphate (ADP) ribosylation [568], facilitated by various enzymes

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Several lines of evidence suggest that activation of inflammatory immune cells induces a shift from oxidative phosphorylation towards aerobic glycolysis with an increase in lactate, like the Warburg effect observed in tumor cells