SPIGFD in these patients were defined by phenotypic and biochemical characteristics and they were treated with recombinant human (rh)IGF-1 in one of the clinical trials leading to approval of this therapy, as described later
Studies in mice confirmed that animals lacking beta-3 receptors showed no response to AOD-9604, proving this pathway is essential to the mechanism
Other side effects that can occur include: Excessive sweat production Rapid weight gain Pain when breathing Shortness of breath when lying down Anxiety Increased or irregular heart rate Numbness, tingling or muscular weakness Increased thirst Urinary frequency B12 injections can also cause allergy symptoms immediately after administration, like difficulty breathing, a swollen throat, mouth, or swelling of the mouth, tongue or face
KEEP OUT OF REACH OF CHILDREN INDICATIONS For use as a supplemental nutritive source of vitamin B12 in cattle, horses, swine, sheep, dogs and cats
