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Hnsch, G

10.3389/fphys.2017.00848 Front Physiol

Here, we reviewed the omics studies related to ASD and the signaling pathways, in particular the convergent signaling pathways (Table S1) which associated with synaptic dysfunction, glutamatergic and GABAergic synapse imbalance, and postsynaptic density (PSD), as well as important physiological and metabolic abnormalities

In humans, small intestinal epithelial cells convert Gln and glutamate to citrulline, which is then transported by the circulatory system to renal proximal tubular cells, where arginine is synthesized by arginine-succinate synthetase and arginine-succinate lyase in the urea cycle