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Hallam and Kolesar observed acute elevation of liver enzymes with hydroxyurea therapy contrary to the effect of L-carnitine reported by Yousefi Rad et al ., in 2019 as it reduced serum alanine transaminase (ALT) and aspartate transaminase (AST) levels only when these aminotransferases are raised or when the duration of supplementation lasts at least 3 months.[ , ] The possible explanation of these conflicting results could be the shorter duration of the current study

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One of them (also labeled as treatment failure) demonstrated good efficacy, yet amitriptyline was discontinued because of narcolepsy, and episodes returned

Both central and peripheral injections of CRF inhibit gastric and proximal small bowel motor activity and induce vomiting in experimental animal and humans (43)