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The interaction of genetics, autoimmunity, oxidative stress and other pathogenetic mechanisms results in damage, dysfunction and apoptosis of MCs, and melanin production is blocked, ultimately leading to vitiligo

Short Acting Beat-2 Agonist (SABA) The generic names for most beta-2 agonists end in (albute ro l , formote rol , salmete rol ) rol Figure 1: Structures of commonly used Beta-2 Agonists, albuterol, a Short-Acting Beta 2 Agonist (SABA) and two Long-Acting Beta 2 Agonists (LABAs) formoterol and salmeterol

Advancing these research avenues can not only enhance treatment efficacy for HAPH, but also deepen our understanding of this disease type, offering scientific insights for public health strategies in high-altitude regions globally

An upregulation of beneficial short-chain fatty acid (SCFA)-producing bacteria, including Faecalibacterium prausnitzii, Eubacterium rectale and Fusicatenibacter saccharivorans