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What we will push back on is the framing

Over a dozen landmark randomized controlled trials (RCTs) have been completed in the past 5 years, including the first head-to-head biologic trials, the first combination biologic studies, and multiple phase III registrational trials of novel compounds with new co-primary and composite end points that will change the treatment landscape for years to come

ESMO Open 9(5):103009 Pienta KJ (2001) Preclinical mechanisms of action of docetaxel and docetaxel combinations in prostate cancer

Despite the existence of such a simple treatment, doctors in the USA, UK, and other countries consistently deny it to patients with B12 deficiency and pernicious anemia