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69,70,71 Indirectly, the disorders probably inhibit melatonin secretion and accelerate the inflammatory response, thus facilitating oncogenesis

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GSH deficiency on hepatocyte epigenetic modifying enzymes Hepatocytes treated with GCLC siRNA showed elevated Dnmt, Tet2, and Tet3, but Tet1 was downregulated, and there was no change in Tdg mRNA expression (Fig