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More important, their results revealed that ACN can significantly decrease MDA levels which is a biomarker for lipid peroxidation secondary to generation of ROS and reduce inflammation by preventing upregulation of pro-inflammatory cytokines, such as Interleukin 6 (IL-6), Interleukin 1b (IL-1b) and chemokine (C-X-C motif) receptor 2 (Cxcr2) (Donepudi et al., 2011)

Due to the lack of DNA repair machinery within the mitochondria, cisplatin-induced mitochondrial DNA damage could not be repaired, which led to the release of cytochrome c from damaged mitochondria and induced apoptosis in DRG neurons (Gill and Windebank, 1998

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