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Additionally, melatonin suppresses other proinflammatory events, such as - amyloid toxicity, NO release, cyclooxygenase-2, and NLRP3 inflammasome activation, TLR4, and mTOR signaling, and cytokine release by senescence-associated secretory phenotype, among others

6.2 Non-pharmacological Approaches 6.2.1 Airway Clearance Techniques Physiotherapy, oscillatory devices, and active cycle breathing techniques help clear mucus from the airways of patients with chronic conditions such as bronchiectasis and CF