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L-Carnitina - descriere

In addition to the above targets, in various disease models, ketone bodies can also act on AMPK-FOXO3 (Forkhead box O3), FOXO1 (Bae et al., 2016), PPAR coactivator 1 alpha (PGC-1) (Kim et al., 2019), NADPH oxidase 4 (NOX4) (Kanikarla-Marie and Jain, 2015), Akt-mTOR (Li et al., 2017) and the MAPK signaling pathway (Li et al., 2022) to exert anti-inflammatory effects, endoplasmic reticulum stress and other pathophysiological processes, which are closely related to the occurrence and development of heart diseases

Interestingly, the COOLAIR lncRNA mediates a cold-induced synchronization from H3K36 methylation to H3K27 methylation, thus repressing the transcriptional activity of FLC

S.WangD.et al