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The negative effects produced by 1 mg/kg of WIN55,212-2 are hypothesized to be due to stronger reductions in Ca 2+ influx, resulting in reduced neuronal activity, which possibly hinders activity-dependent myelination (Tomas-Roig et al., 2020)

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Three of the previously characterized L1 GUS enzymes, Ec GUS, Sa GUS, and Cp GUS, were singletons that did not group with any other GUS enzyme, while Ee GUS clustered with two other GUS enzymes from bacteria identified as Eubacterium sp