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The classic structure of the NLRP3 inflammasome (NOD-Like Receptor Protein 3 Inflammasome) comprises three parts: a central nucleotide-binding oligomerization domain (referred to as NACHT), a C-terminal leucine-rich repeat (LRR) domain, and an N-terminal effector domain (the pyrin domain, or PYD), which interacts with downstream signaling molecules to promote pyroptosis

Epidemiological projections suggest that by 2025, around 322 million men worldwide will be affected by ED [37, 38]

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