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Further, it seems odd to start off with these disorders because there is nothing cited to specifically implicate ghrelin therapeutics for these conditions. Response: In order to reduce speculation, we have removed the sections on D1R-GHSR1as possible role in Alzheimers, 5-HT2C-GHSR1as possible role in depression, anxiety, and stress, and D2R-GHSR1as possible role in antipsychotic-associated weight gain (although we have added an additional section pertaining to 5-HT2C-GHSR1as possible role in schizophrenia, along with considerable references to support our argument)