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At the molecular level, it seems that the mechanisms of action vary depending on the dose of metformin used and duration of treatment

The glutaredoxin (Grx)/GSH/GSH reductase (Gor) system catalyzes specific de-glutathionylation of S -glutathionylated proteins (Fernandes and Holmgren, 2004

The protein concentrations in the supernatants were determined by Lowry's method [18]

At the same time, they strongly inhibit active oxygen and scavenge free radicals, and can reduce lipid peroxidation caused by iron overload, which results in cell damage