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These include unexplained fatigue or energy changes, significant mood alterations, palpitations or irregular heartbeat, increased sensitivity to heat or cold, changes in bowel habits beyond expected medication side effects, unexplained hair loss, or skin changes

Immune infiltration analysis and its correlation with feature genes The single sample gene set enrichment analysis (ssGSEA) algorithm of GSVA R package (version 1.50.5, was utilized to calculate the proportion of 28 immune cell types based on the expression levels of samples in the training set

Non-linear and multidimensional responses

MRP, multidrug resistance-associated protein