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Additionally, the N-terminal tryptophan is among the more oxidation-prone and light-sensitive residues

lateral ventricle and medial preoptic area injections demonstrated local effects The subcutaneous route ultimately proved most suitable for clinical development, offering reliable absorption, manageable side effects, and practical at-home self-administration

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The duration of the trial was three years with 3862 patients exposed to Reclast and 3852 patients exposed to placebo administered once annually as a single 5 mg dose in 100 mL solution infused over at least 15 minutes, for a total of three doses