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Meta-analyses of clinical trials indicate that KD leads to faster weight loss in the short term, with optimal results usually achieved within the first 36 months (71, 72)

The increase in lactate that we detected points towards a defect in oxidative energy metabolism, but this conclusion must be treated cautiously given the difficulty of measuring lactate in the presence of the much larger and broader macromolecule (MM) resonance at ~1.35 ppm, with the lactate signal being a small shoulder on that peak (Fig

doi: 10.1111/ejn.v53.12 52 ReayWRCairnsMJ

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