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Main Study Findings and Authors Conclusions Table 8Summary of Findings Included Systematic Review and Meta-Analysis OR = Odds Ratio, CI = Confidence Interval, RRR = Relative Risk Reduction, NNT = Number Needed to Treat Table 9Summary of Findings of Included Non-Randomized Study Table 10Summary of Recommendations of Included Guidelines RCT = Randomized Controlled Trial, CI = Confidence Interval Appendix 5

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We observed that only a small quantity of TNR molecules was found in Rab5-positive early endosomes and Rab7- or Rab11-positive late or recycling endosomes (Fig