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This study indicates that alterations in the age-associated methylation of candidate genes in sperm might contribute to the increased incidence of neuropsychiatric, and other disorders in the offspring of older males

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Notably, a clinical trial involving 12 weeks of oral CU administration observed a reduction in insulin resistance in type 2 diabetes, which was associated with its effects on A protein accumulation and tau protein hyperphosphorylation (Thota et al., 2020) (Table 2)

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