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Elevated Hcy leads to an increase in the generation of mitochondrial ROS, resulting in oxidative damage at the cellular and molecular levels, and suppression of antioxidant enzyme systems (Kaplan et al., 2020)

According to this trial, which examined a population with T2DM and established cardiovascular disease,1.8mg liraglutide daily showed statistically significant reduction of cardiovascular death, of non-fatal myocardial infarction (heart attack), and of non-fatal stroke by 13% versus placebo, when added to standard care

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Continuing into the duodenum, pancreatic proteases act on the Hc- Cbl complex