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Conducting rigorous studies like those that established the benefits of injectable GLP-1 RAs such as tirzepatide, semaglutide, dulaglutide, and liraglutide on CKD, MASH, and cardiovascular outcomes will be crucial in determining the full clinical utility of these novel agents

The von Frey filaments were applied perpendicularly against the plantar surface of hindpaw until the fibers bowed, and then held for 3 s

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The drug was then drawn up using a micropipette with a clean tip and applied carefully to the rim of the mouse nostril, one drop at a time