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The FOXO subfamily of Forkhead transcription factors is a direct downstream target of the PI3K/Akt pathway [110]

Pharmaceutical giant GlaxoSmithKline (GSK) purchased Sinclairs company for the tidy sum of $720 million, only to discover that they could not successfully reproduce Sinclairs results.11 By this point, research into resveratrol had already taken off, as Sinclairs savvy for self-promotion and media relations had made resveratrol an easy target for researchers looking to get published in scientific journals