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The resolutions of the final consensus maps were 2.2 , 2.2 , 2.7 and 3.0 for the CTR, AMY 1 R, AMY 2 R and AMY 3 R, respectively, determined at gold standard Fourier shell correlation (FSC) 0.143 (Fig

162,163 Simultaneously, the accumulated PARs at DNA break sites are required for the recruitment of DNA repairs, including XRCC1, DDB2, ALC1, RECQ1, CHD2, BRCA1, Ligase V, MRE11 and NBS1, to initiate DNA repair