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Eight rats were perfused with fixative for histological preparation and analysis of the brains

10.1007/s00401-016-1655-9 Acta Neuropathol

However, under the MDD pathological condition, due to the decreased expression of EAATs in astrocytes, excessive glutamate in the synaptic cleft activates synaptic mGluRs, which leads to neuronal excitotoxicity