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Primitive hematopoietic progenitor cells were enriched from the BM using the Mouse Lineage Cell Depletion Kit (Miltenyi Biotec Inc., Auburn, CA)

doi: 10.1038/s41591-018-0136-1 40 HoshidaYBrunetJPTamayoPGolubTRMesirovJP

Hyperglycemia, increased sorbitol and protein kinase C, elevated homocysteine, reduced nitric oxide and excessive Reactive Oxygen Species (ROS) damage endothelial tissue and produce a rheological change that increases vascular resistance and reduces blood flow to the nerve 3.3 Risk factors Diabetes is the strongest risk factor for DPN, along with certain disease characteristics such as diabetes duration and poor glycemic control in terms of fasting blood glucose (FBG), glycated hemoglobin (HbA1c