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Thus, we determined ER-stress response genes Xbp1 and the ER chaperone heat shock 70 kDa protein 5 (HSPA5, previously known as immunoglobulin heavy chain binding protein [BIP]), inflammation-responsive genes IL6 and IL1, and hypoxia-responsive genes hypoxia-inducible transcription factor 1 (HIF1) and GAPDH

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Supportively the xenografts of these ER-negative 4T1 and MDA-MB-231 breast cancer cells grow larger and are more metastatic with high cholesterol diet

In these papers, GSTP phosphorylation is linked with its catalytic activity and drug resistance of tumor cells rather than the translocation of GSTP from the cytoplasm to nucleus