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Further use of the RIPK1 inhibitor Nec-1 simultaneously suppressed the core components of both pathways, revealing their synergistic role in RPE injury

J Pineal Res (2011) 50(3):26771

But you might need them more often if you have more serious symptoms, like nerve problems, or your pernicious anemia is serious

Conclusion: HEV RNA response-guided treatment results in a higher treatment success rate than a fixed 12-week ribavirin regimen in immunosuppressed patients