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Barth, C

3.3 Targeting BCL-2 family proteins: innovative strategies for directly activating BAX/BAK in cancer treatment Apoptosis, the primary mechanism of cell death in cancer cells, is meticulously regulated by BCL-2 family proteins (Singh et al., 2019)

While p53 has been classically recognized to impede cancer development by mediating cell cycle arrest, apoptosis, and senescence, new evidence suggests that p53 can induce ferroptosis in cancer cells by regulating metabolic activities