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Inhibition of the FlAsH-sensitized TCPTP mutants is rapid and specific, and strong FlAsH sensitivity is observed in mutants that contain as few as two cysteine point mutations in their engineered WPD loops, minimization of FlAsH-binding determinants, overview fluorescein arsenical hairpin binder fluorescein arsenical hairpin binder does not inhibit any wild type PTP, but insertion of a fluorescein arsenical hairpin binder-binding peptide (CCPGCC) at a conserved position in the PTP catalytic-domain's WPD loop confers fluorescein arsenical hairpin binder sensitivity upon divergent PTPs - glycyrrhetic acid - - Glyoxal - 93% remaining activity at 0.5 mM glyoxalbis(N(4)-methylthiosemicarbazonato)Cu(II) - inhibition of protein tyrosine phosphatase activity is the prerequisite for activation of epidermal growth factor receptor by the compound, overview H2O2 H3VO4 heparin hesperetin uncompetitive inhibition hesperetin 5-O-glucoside mixed-type inhibition - hesperetin 7-O-glucoside low inhibition hesperidin mixed-type inhibition

The test results of the batches are published transparently on the Cologne list.

Zhang W, Cui N, Ye J, Yang B, Sun Y, Kuang H

The best fitting networks are scored according to the Akaike Information Criterion