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Similarly, folate from mothers reserves keeps getting passed to the baby irrespective of the mothers diet [6]

The absence of a safety mechanism or switch further increases the risk of severe or fatal side effects, such as tumor lysis syndrome and cytokine release syndrome (Jureczek et al., 2019)

One of the main challenges in the development of an efficient anti-cancer vaccine is the limited ability of tumor-associated antigens to overcome immune tolerance [12]

In addition, epithelial carcinoma cells exposed to cisplatin, 5-flourouracil and docetaxel demonstrate a drug resistance phenotype that has been shown by oxidative damage adaptation through Nrf2 upregulation and autophagy-mediated clearance of toxic p62 aggregates (58)